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- Title
Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson's Disease.
- Authors
Koppula, Sushruta; Kumar, Hemant; In Su Kim; Dong-Kug Choi
- Abstract
Reactive oxygen species (ROSs) are emerging as important players in the etiology of neurodegenerative disorders including Parkinson's disease (PD). Out of several ROS-generating systems, the inflammatory enzymes nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and inducible nitric oxide synthase (iNOS) were believed to play major roles.Mounting evidence suggests that activation of NADPH oxidase and the expression of iNOS are directly linked to the generation of highly reactive ROS which affects various cellular components and preferentially damagemidbrain dopaminergic neurons in PD. Therefore, appropriate management or inhibition of ROS generated by these enzymes may represent a therapeutic target to reduce neuronal degeneration seen in PD. Here, we have summarized recently developed agents and patents claimed as inhibitors of NADPH oxidase and iNOS enzymes in experimental models of PD.
- Subjects
REACTIVE oxygen species; ENZYME inhibitors; INFLAMMATION; NADPH oxidase; PARKINSON'S disease; NITRIC-oxide synthases; NEURODEGENERATION
- Publication
Mediators of Inflammation, 2012, Vol 2012, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2012/823902