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- Title
Evaluating serum periostin levels in allergic bronchopulmonary aspergillosis.
- Authors
Tanaka, Jun; Hebisawa, Akira; Oguma, Tsuyoshi; Tomomatsu, Katsuyoshi; Suzuki, Junko; Shimizu, Hiroshige; Kawabata, Yoshinori; Ishiguro, Takashi; Takayanagi, Noboru; Ueda, Soichiro; Fukunaga, Koichi; Taniguchi, Masami; Ono, Junya; Ohta, Shoichiro; Izuhara, Kenji; Asano, Koichiro
- Abstract
Serum periostin levels were equivalent in ABPA patients regardless of the asthma comorbidity: 106 (76-139) ng/mL in patients with asthma (n = 33) and 109 (74-149) ng/mL without asthma (n = 11). Serum periostin levels, relatively consistent regardless of the treatment with systemic corticosteroids,[6] might be a more robust diagnostic biomarker than peripheral blood eosinophil counts or serum IgE levels in patients with severe asthma under systemic corticosteroids. In conclusion, serum periostin concentrations in ABPA/ABPM patients were elevated, reflecting its enhanced expression in the bronchi and peripheral lungs, and can be useful for the diagnosis of ABPA even in the patients pretreated with systemic corticosteroids.
- Subjects
BRONCHIECTASIS; PULMONARY aspergillosis; SERUM; CRYPTOGENIC organizing pneumonia
- Publication
Allergy, 2020, Vol 75, Issue 4, p974
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14114