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- Title
Age and early maternal smoking contribute to epithelial cell IL‐13 responsiveness in a pediatric asthma population.
- Authors
McAlees, Jaclyn W.; Baker, Theresa; Kaur, Davinder; McKnight, Christopher; Lindsley, Andrew; Strait, Richard T.; Zhang, Xue; Biagini Myers, Jocelyn M.; Butsch Kovacic, Melinda; Lewkowich, Ian P.
- Abstract
Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population Although not statistically significant, cells from children with moderate or severe asthma trended toward greater IL-13-induced STAT6 activation compared to children with mild asthma ( I P i = 0.25; Table). However, children whom had experienced asthma symptoms within the past 4 weeks (ie, Maximum Respiratory Symptom Score (MRSS) > 0; 89.4% of participants) had significantly more IL-13-induced STAT6 activation compared to those without recent symptoms ( I P i = 0.040; Figure C, Table). The ongoing assessment of IL-13-induced STAT6 activation in the entire PEES population will further increase our power to detect associations between asthma severity and IL-13-induced STAT6 activation.
- Subjects
WHEEZE; BREATH holding; MATERNAL age; EPITHELIAL cells; ASTHMA; SMOKING
- Publication
Allergy, 2019, Vol 74, Issue 12, p2485
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.13876