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- Title
Prevalence and clinical relevance of local allergic rhinitis.
- Authors
Rondón, C.; Campo, P.; Galindo, L.; Blanca-López, N.; Cassinello, M. S.; Rodriguez-Bada, J. L.; Torres, M. J.; Blanca, M.
- Abstract
Background Evidence demonstrates the existence of local allergic rhinitis ( LAR) in nonatopic patients, although its prevalence in the rhinitis population remains unknown. The aim, therefore, of this study was to evaluate the prevalence, clinical characteristics, and severity of LAR in a Spanish rhinitis population, compared with patients having classical allergic rhinitis ( AR) with systemic atopy or nonallergic rhinitis ( NAR). Methods A group of 452 adult rhinitis patients were randomly selected from a total of 3860 who attended our allergy service over 1 year. A clinical questionnaire, skin prick test ( SPT), spirometry, and serum total and specific IgE ( sIgE) were evaluated. A nasal allergen provocation test with multiple aeroallergens (NAPT-M), including Dermatophagoides pteronyssinus, pollens, alternaria, and dog epithelia, was performed in patients with negative SPT and serum sIgE. Results A total of 428 patients completed the study; 24 were excluded because of nasal hyper-reactivity. LAR was diagnosed in 25.7%, AR in 63.1%, and NAR in 11.2%. The LAR and AR patients had a similar clinical profile: a nonsmoking woman with severe, persistent perennial rhinitis frequently associated with conjunctivitis and asthma. More than 36% of LAR patients reported rhinitis onset in childhood. NAPT-M detected aeroallergen polysensitization in 37.3% of the LAR patients. Dermatophagoides pteronyssinus was the main sensitizing aeroallergen in LAR and AR (60% vs 54%, P > 0.05). Conclusions Local allergic rhinitis is a prevalent entity in patients evaluated with rhinitis. Persistent and severe symptoms associated with conjunctivitis and/or asthma and polysensitization were likely to be detected in LAR and AR.
- Subjects
ALLERGIC rhinitis; ASTHMA; CONJUNCTIVITIS; ALLERGENS; DERMATOPHAGOIDES pteronyssinus; ALTERNARIA; POLLEN
- Publication
Allergy, 2012, Vol 67, Issue 10, p1282
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12002