We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immunohistological evaluation of patients treated with intra-arterial chemoradiotherapy and surgery for oral cancer.
- Authors
Ikeuchi, Yutaro; Someya, Masanori; Hasegawa, Tomokazu; Saito, Masato; Mafune, Shoh; Tsuchiya, Takaaki; Kitagawa, Mio; Gocho, Toshio; Dehari, Hironari; Ogi, Kazuhiro; Sasaki, Takanori; Hirohashi, Yoshihiko; Torigoe, Toshihiko; Hirokawa, Naoki; Miyazaki, Akihiro; Sakata, Koh-ichi
- Abstract
Preoperative intra-arterial chemoradiotherapy (IACRT) can improve the outcome and reduce the extent of surgery in patients with advanced oral cancer. However, the response to this regimen varies among patients, which may be related to the immune status of the tumor. We investigated the effects of proteins involved in tumor immunity on the outcomes of combined IACRT and surgery for oral cancer. We examined CD8 + and FoxP3 + tumor-infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) expression on immune cells and tumor cells in pretreatment biopsy samples from 69 patients diagnosed with oral cancer treated with IACRT at our institution during 2000–2020. Patients with abundant CD8 + TILs had significantly better 5-year disease-specific survival (DSS) compared to that of patients with less infiltration of these cells (P = 0.016). Patients with higher FoxP3 + T-cells invasion had significantly better DSS compared to that of less FoxP3 (P = 0.005). Patients with high PD-L1 expression in tumor cells and immune cells had significantly better DSS than that of patients with low PD-L1 expression in these cells (P = 0.009 and P = 0.025, respectively). Collectively, these results suggest that the tumor immune microenvironment could affect outcomes of IACRT treatment in oral cancer.
- Subjects
PROGRAMMED cell death 1 receptors; ORAL cancer; ORAL surgery; ONCOLOGIC surgery; CANCER patients; CHEMORADIOTHERAPY
- Publication
Medical Molecular Morphology, 2023, Vol 56, Issue 4, p288
- ISSN
1860-1480
- Publication type
Article
- DOI
10.1007/s00795-023-00367-8