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- Title
Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure.
- Authors
Kien, C. Lawrence; Bunn, Janice Y.
- Abstract
Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure C. Lawrence Kien and Janice Y. Bunn. Departments of Pediatrics, Medicine, and Medical Biostatistics, University of Vermont, Burlington, VT. There are opposing effects of estrogen and testosterone on transcription factors regulating mitochondrial function. We assessed the effects of dietary palmitic acid (PA) versus oleic acid (OA) on fatty acid (FA) oxidation and daily energy expenditure (DEE) in males and females, who had participated in a previously described clinical trial (AJCN 82:320, 2005). Adults (N =43) were studied after a baseline diet (PA = 8.4% kcal, OA = 13.1% kcal) and after one of two experimental diets: HI PA (PA = 16.8 %, OA = 16.4% kcal) (N=21; 11 males) or HI OA (PA = 1.7 %, and OA = 31.4%) (N=22; 11 males). Relative to baseline, the rate of FA oxidation (% resting energy expenditure) (mean ± SEM) increased in females on HI OA while decreasing on HI PA in both the fed (+11.8 ± 5.6% vs. - 6.3 ± 4.2%, P = 0.02) and fasting states (+13.4 ± 4.2 % vs. -12.7 ± 6.9 %, P = 0.047), but in males changed only in the fed state (-11.1 ± 10.7 vs. - 7.1 ± 4.1% kcal, P = 0.046)(Figure). DEE changed only in males, increasing on HI OA and decreasing on HI PA (+66 ± 61 kcal · d-1 or 1.2 ± 1.0 kcal · kg fat-free mass-1 · d-1 vs. -266 ± 78 or -4.2 ± 1.3, P = 0.004 and 0.007 respectively). Increased dietary PA/OA caused decreased FA oxidation in females, in the fed and fasted states, with less effect in males, and decreased DEE in males.
- Subjects
GENDER; PALMITIC acid; OLEATES; OXIDATION; CALORIC expenditure
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA101
- ISSN
0892-6638
- Publication type
Article