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- Title
Longitudinal extensive transverse myelitis following ChAdOx1 nCOV-19 vaccine: a case report.
- Authors
Tan, Wee Yong; Yusof Khan, Abdul Hanif Khan; Mohd Yaakob, Mohd Naim; Abdul Rashid, Anna Misyail; Loh, Wei Chao; Baharin, Janudin; Ibrahim, Azliza; Ismail, Mohd Redzuan; Inche Mat, Liyana Najwa; Wan Sulaiman, Wan Aliaa; Basri, Hamidon; Hoo, Fan Kee
- Abstract
<bold>Background: </bold>Transverse myelitis (TM) is a relatively uncommon condition, and vaccine-associated myelitis is even rarer. Concern regarding neurological complications following vaccination escalated following the report of TM during the safety and efficacy trials of the COVID-19 vaccine.<bold>Case Presentation: </bold>We report the first case of Longitudinal Extensive Transverse Myelitis (LETM) in Malaysia following administration of the chimpanzee adenovirus-vectored (ChAdOx1 nCoV-19) vaccine. A 25-year-old female presented with bilateral lower limb weakness and inability to walk with a sensory level up to T8 with absent visual symptoms. Urgent gadolinium-enhanced magnetic resonance imaging (MRI) of the spine showed long segment TM over the thoracic region. Cerebrospinal fluid autoantibodies for anti-aquaporin-4 and anti-myelin-oligodendrocyte were negative. A diagnosis of LETM following vaccination was made, and the patient was started on a high dose of intravenous methylprednisolone. The patient eventually made a recovery following treatment.<bold>Conclusion: </bold>LETM is a rare but serious adverse reaction following vaccination. Previously reported cases showed an onset of symptoms between 10 to 14 days post-vaccination, suggesting a delayed immunogenic reaction. However, the incidence of myelitis in COVID-19 is much more common, far greater than the risk associated with vaccination.
- Publication
BMC Neurology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-021-02427-x