We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study.
- Authors
Hannah Lui Park; Argyrios Ziogas; Jenny Chang; Bhumi Desai; Bessonova, Leona; Garner, Chad; Eunjung Lee; Neuhausen, Susan L.; Wang, Sophia S.; Huiyan Ma; Clague, Jessica; Reynolds, Peggy; Lacey Jr, James V.; Bernstein, Leslie; Anton-Culver, Hoda; Park, Hannah Lui; Ziogas, Argyrios; Chang, Jenny; Desai, Bhumi; Lee, Eunjung
- Abstract
<bold>Background: </bold>The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one's subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner.<bold>Methods: </bold>Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes.<bold>Results: </bold>Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95% CI 1.34-2.92, uncorrected p = 0.0005).<bold>Conclusions: </bold>While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype.
- Subjects
CALIFORNIA; BREAST cancer risk factors; SINGLE nucleotide polymorphisms; CHEMOPREVENTION; CASPASES; RALOXIFENE; TAMOXIFEN; THERAPEUTICS; BREAST tumors; CELL receptors; DISEASE susceptibility; GENETIC polymorphisms; GENETIC techniques; PROTEINS; GENOTYPES
- Publication
BMC Cancer, 2016, Vol 16, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-015-2036-9