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- Title
Three different approaches to C-H bond functionalization in the synthesis of antitumor alkaloids rhazinilam, rhazinal and rhazinicine.
- Authors
Le Floc'h, Delphine; Gouault, Nicolas; David, Michèle; van de Weghe, Pierre
- Abstract
In the past decade, metal catalyzed or promoted C-H bond activation appears as an attractive alternative to classical cross-coupling reaction. Although the studies of this methodology have grown considerably, applications in total synthesis of natural products remain rare. This short review will focus on the use of the metal catalyzed or promoted C-H bond functionalization for the total synthesis of rhazinilam and congeners and demonstrate the usefulness and the efficiency of this approach.
- Subjects
CHEMICAL reactions; CHEMICAL bonds; ORGANIC synthesis; ANTINEOPLASTIC agents; CATALYSIS; RING formation (Chemistry); PHYSICAL &; theoretical chemistry
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2010, p247
- ISSN
1551-7004
- Publication type
Article