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- Title
Iridocorneal endothelial syndrome: Evaluation of patient demographics and endothelial morphology by confocal microscopy in an Indian cohort.
- Authors
Malhotra, Chintan; Seth, Natasha; Pandav, Surinder; Jain, Arun; Kaushik, Sushmita; Gupta, Amit; Raj, Srishti; Dhingra, Deepika; Seth, Natasha G; Pandav, Surinder S; Jain, Arun K
- Abstract
<bold>Purpose: </bold>To evaluate the patient demographics and morphological characteristics of corneal endothelium by in vivo confocal microscopy (IVCM), in patients with Iridocorneal Endothelial (ICE) Syndrome.<bold>Methods: </bold>In this retrospective observational series, IVCM acquired endothelial images of patients with ICE syndrome were evaluated. 'ICE cells' morphology was classified as "-" or "+" if they were larger or smaller than contralateral normal endothelium. It was correlated with patient demographics and clinical manifestations.<bold>Results: </bold>IVCM was performed on 41 eyes of 21 patients, with 13 males (62%) and 8 females (38%). The disease was unilateral in 19 (90.5%) and bilateral but asymmetric in two (9.5%) patients. Total ICE was seen in 91% eyes. Eighty percent patients (12 out of 15) with ICE-cells were males while 83.3% (5 out of 6) patients with ICE + cells were females. Mean age of patients with ICE- cell type and ICE + cell type was 45.8 ± 17.8 years and 40.3 ± 9.2 years respectively (P = 0.02). Both ICE - and ICE + eyes had similar incidence (33.3%) of corneal edema. ICE + eyes had more severe (grades 2/3) glaucoma (n = 5/6 eyes, 83.3%) compared to ICE - eyes (n = 8/15 eyes, 53.3%).<bold>Conclusion: </bold>A male preponderance, predilection of ICE - and + cell variants for male and female gender respectively, lack of association of the endothelial cell morphology with corneal edema, and apparent association of ICE + phenotype with more severe glaucoma occurring at a relatively younger age, are some novel findings of the present study. In the clinical setting correlation of patient demographics with these IVCM findings may help in better long-term prognostication of eyes with ICE syndrome.
- Subjects
INDIA; CONFOCAL microscopy; CORNEAL dystrophies; EDEMA; MORPHOLOGY; DEMOGRAPHIC surveys; CELL morphology; ENDOTHELIAL cells; ENDOTHELIUM; MICROSCOPY; PROGNOSIS; RETROSPECTIVE studies; SEX distribution; DISEASE prevalence; DEMOGRAPHY; LONGITUDINAL method
- Publication
Indian Journal of Ophthalmology, 2019, Vol 67, Issue 5, p604
- ISSN
0301-4738
- Publication type
journal article
- DOI
10.4103/ijo.IJO_1237_18