We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymorphisms in the transforming growth factor-β<sub>1</sub> gene ( TGF-β<sub>1</sub>) and the risk of advanced alcoholic liver disease.
- Authors
Oliver, Javier; Agúndez, José A. G.; Morales, Sonia; Fernández-Arquero, Miguel; Fernández-Gutierrez, Benjamín; de la Concha, Emilio G.; Díaz-Rubio, Manuel; Martín, Javier; Ladero, José M.
- Abstract
There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor β1 (TGF-β1) is the main cytokine involved in liver fibrogenesis. The TGF-β1 gene is polymorphic at several sites and these polymorphisms are probably related to differences in the rate of TGF-β1 synthesis. Our aim has been to analyse the influence of the TGF-β1 gene polymorphisms in the predisposition to advanced alcoholic liver disease (ALD) in ethanol abusers. Methods: TGF-β1 single nucleotide polymorphisms at positions –509 (C or T), +869 (C or T, codon 10), and +915 (C or G, codon 25) were examined in 165 alcoholics with advanced ALD and in 185 healthy controls. Results: Among the 94 male patients with oesophageal varices, those carrying the GG genotype at position +915 were diagnosed at an older age than the remaining patients (age 52.1 years, standard deviation (SD) 9.9 vs. 45 SD 13.4, P=0.012). No other statistically significant differences were found in the distribution of the three TGF-β1 polymorphisms analysed individually or as combined haplotypes. Conclusions: The polymorphisms at the TGF-β1 gene analysed in this study are probably not related to the risk of advanced ALD.
- Subjects
ALCOHOLIC liver diseases; COMPLICATIONS of alcoholism; LIVER diseases; GROWTH factors; GENETIC polymorphisms; POPULATION genetics
- Publication
Liver International, 2005, Vol 25, Issue 5, p935
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2005.01150.x