We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Exploring polymorphisms of the bovine RARRES2 gene and their associations with growth traits.
- Authors
Zhang, Ya; Zhu, Jinlong; Wang, Chen; Sun, Jiajie; Lai, Xinsheng; Xu, Yao; Lan, Xianyong; Lei, Chuzhao; Zhang, Chunlei; Yang, Donbgying; Chen, Hong
- Abstract
Retinoic acid receptor responder 2 gene ( RARRES2) encodes a novel adipokine protein that plays a crucial role in regulating several biological processes, including immune responses, adipocyte differentiation, type 2 diabetes and metabolic syndrome. In this paper, polymorphisms of the bovine RARRES2 gene were detected in 1300 individuals from six breeds by DNA pooling, CRS-PCR-RFLP and DNA sequencing methods. The results showed that NC_007302:g.117035859A>G, 117035706G>A and 117034290A>G were in the coding region, which resulted in three synonymous mutations and only 117033779C>G was in the 3′ UTR. Additionally, associations of the four novel SNPs with growth traits were analyzed in Nanyang cattle up to 2 years of age. In P1- PvuII locus, individuals with genotype BC had greater body height and hucklebone width than those with genotype AA, AC and AB at the age of 24 months. In P3- BamHI locus, individuals with genotype AG had higher hucklebone width than those with genotype GG at the age of 24 months. However, no statistically significant differences were observed in P5- SmaI locus. These results indicated that RARRES2 gene might be a potential candidate gene for marker-assisted selection (MAS).
- Subjects
TRETINOIN; IMMUNE response; TYPE 2 diabetes; METABOLIC syndrome; DNA; CATTLE genetics
- Publication
Molecular Biology Reports, 2012, Vol 39, Issue 3, p2305
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-011-0980-2