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- Title
X-linked genes exhibit skewed expression in Sjogren's disease (SjD): a further step toward understanding the female predominance of autoimmune disease.
- Authors
Fox, Robert
- Abstract
I Epidemiologic studies have shown that over 80% of autoimmune disease patients are female. i SjD is a chronic autoimmune disease, characterized by aberrant innate and adaptive immune response leading to exocrine gland lymphocytic infiltrates, with an impressive female-to-male ratio of 9:1 [[8]]. The cell lines were derived from patients with Sjogren's disease (SjD) and were compared to the results from cell lines from females I lacking i autoimmune disease. This unequal silencing was not an artifact of a single cell line, but was found in 4 differently established salivary mesenchymal cell lines derived from SjD subjects, while I not i observed in 4 I control i female cell lines.
- Subjects
SJOGREN'S syndrome; X chromosome; AUTOIMMUNE diseases; MEDICAL students; SYSTEMIC lupus erythematosus
- Publication
Journal of Molecular Medicine, 2022, Vol 100, Issue 9, p1267
- ISSN
0946-2716
- Publication type
Article
- DOI
10.1007/s00109-022-02223-1