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- Title
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes.
- Authors
Kaneto, Hideaki; Matsuoka, Taka-aki; Nakatani, Yoshihisa; Kawamori, Dan; Miyatsuka, Takeshi; Matsuhisa, Munehide; Yamasaki, Yoshimitsu
- Abstract
Pancreatic β-cell dysfunction and insulin resistance are observed in type 2 diabetes. Under diabetic conditions, oxidative stress and ER stress are induced in various tissues, leading to activation of the JNK pathway. This JNK activation suppresses insulin biosynthesis and interferes with insulin action. Indeed, suppression of the JNK pathway in diabetic mice improves insulin resistance and ameliorates glucose tolerance. Thus, the JNK pathway plays a central role in pathogenesis of type 2 diabetes and may be a potential target for diabetes therapy.
- Subjects
TYPE 2 diabetes; INSULIN resistance; OXIDATIVE stress; IMMUNOSUPPRESSION; PEOPLE with diabetes; BIOSYNTHESIS; THERAPEUTICS
- Publication
Journal of Molecular Medicine, 2005, Vol 83, Issue 6, p429
- ISSN
0946-2716
- Publication type
Article
- DOI
10.1007/s00109-005-0640-x