We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease.
- Authors
Safranow, Krzysztof; Rzeuski, Ryszard; Binczak-Kuleta, Agnieszka; Czyzycka, Edyta; Skowronek, Janusz; Jakubowska, Katarzyna; Wojtarowicz, Andrzej; Loniewska, Beata; Ciechanowicz, Andrzej; Kornacewicz-Jach, Zdzislawa; Chlubek, Dariusz
- Abstract
Background/Aims: The common G22A polymorphism in the adenosine deaminase (ADA) gene leads to substitution Asp8Asn. The lower activity of the enzyme encoded by A22 (ADA*2) allele may increase tissue concentrations of adenosine, a potent cardioprotective agent. In a case-control study, we investigated the association between ADA polymorphism and coronary artery disease (CAD). Methods: A hundred and seventy-one CAD patients from the north-western part of Poland and 200 consecutive newborns from the same population were genotyped by PCR-RFLP. Results: Twenty-five ADA*1/*2 heterozygotes (12.5%) and 2 ADA*2/*2 homozygotes (1%) were found in the control group, while only 10 *1/*2 heterozygotes (5.9%) and no *2/*2 homozygotes were found in the CAD group. Frequencies of ADA*2 carriers (5.9% vs. 13.5%, p = 0.015) and ADA*2 allele (2.9% vs. 7.3%, p = 0.0083) were lower in CAD patients than in controls. Among CAD patients, a significantly lower proportion of *2 allele carriers was treated with diuretics and ACE inhibitors when compared to *1/*1 wild-type homozygotes. Conclusion: ADA*2 allele may decrease genetic susceptibility to CAD. ADA should be added to the list of candidate genes modifying the risk of cardiovascular diseases. Copyright © 2007 S. Karger AG, Basel
- Subjects
ADENOSINE deaminase; GENETIC polymorphisms; CARDIOTONIC agents; CORONARY arteries; ACE inhibitors; CARDIOVASCULAR diseases
- Publication
Cardiology, 2007, Vol 108, Issue 4, p275
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000099096