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- Title
Renal Biomarkers and Novel Therapies in Pediatric Nephrology: From Chronic Kidney Disease to Renal Transplantation.
- Authors
Chirico, Valeria; Chimenz, Roberto
- Abstract
Chronic kidney disease (CKD), a growing problem with an estimated prevalence of 74.7 cases per million children, induces high morbidity, mortality, and poorer quality of life [[1]]. Next-generation sequencing accelerated the etiological diagnosis of CAKUT and inherited nephropathies with an accurate diagnosis and prognostic information, achieving a personalization of therapy and analyses of the risks related to the diseases [[9]]. 10.1056/NEJMoa2021712 12 Gou P., Leng J., Cheng X., Zhang J. Clinical evaluation, accurate diagnosis and treatment of four pedigrees with Fabry's disease. These are examples of rare diseases with an underestimated incidence due to a poor diagnosis but with a great potential to change the natural history of the disease, based on dialysis and transplantation, by newly available therapies.
- Subjects
CHRONIC kidney failure; PEDIATRIC therapy; PEDIATRIC nephrology; KIDNEY transplantation; URINARY tract infections; KIDNEY diseases
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 11, p3810
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12113810