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- Title
The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients.
- Authors
Kobayashi, Shuzo; Ohtake, Takayasu
- Abstract
Patients undergoing hemodialysis (HD) experience serious cardiovascular complications, through malnutrition, inflammation, and atherosclerosis. Amputation for peripheral arterial disease (PAD) is more prevalent in patients undergoing HD than in the general population. In addition, revascularization procedures in dialysis patients are often associated with subsequent amputation and high mortality rates. To improve the prognosis of dialysis patients, malnutrition and inflammation must be properly treated, which necessitates a better understanding of the characteristics of dialysis membranes. Herein, the characteristics of several dialysis membranes were studied, with a special reference to the AN69 membrane, noting several similarities to low-density lipoprotein (LDL)-apheresis, which is also applicable for the treatment of PAD. Both systems (LDL-apheresis and AN69) have anti-inflammatory and anti-thrombogenic effects because they use a negatively charged surface for extracorporeal adsorptive filtration from the blood/plasma, and contact phase activation. The concomitant use of both these therapeutic systems may have additive therapeutic benefits in HD patients. Here, we reviewed the characteristics of dialysis membranes and benefits of the AN69 membrane in dialysis patients.
- Subjects
HEMODIALYSIS patients; HEMAPHERESIS; DIALYSIS (Chemistry); PERIPHERAL vascular diseases; HEMODIALYSIS; BLOOD filtration
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 3, p1123
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12031123