We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy.
- Authors
Sartini, Marina; Del Puente, Filippo; Oliva, Martino; Carbone, Alessio; Blasi Vacca, Elisabetta; Parisini, Andrea; Boni, Silvia; Bobbio, Nicoletta; Feasi, Marcello; Battistella, Alessandra; Pontali, Emanuele; Cristina, Maria Luisa
- Abstract
Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the effects of these changes. Methods. Data from a hospital in Genoa, Italy, were analysed. Patients deceased from SARS-CoV-2 infection were selected. Data were compared by dividing patients into two cohorts: "phase A" (March–May 2020) and "phase B" (October–December 2020). Results. A total of 5142 patients were admitted. There were 274 SARS-CoV-2-related deaths (162 phase A and 112 phase B). No differences were observed in terms of demographics, presentation, or comorbidities. A significant increase was recorded in corticosteroid use. Mortality was 33.36% during phase A, falling to 21.71% during phase B. When subdividing the trend during the two phases by age, we found a difference in people aged 65–74 years. Conclusions. There is scarce evidence regarding treatment for SARS-CoV-2 (especially for severe infection). However, treatment changes improved the prognosis for people under the age of 75. The prognosis for older people remains poor, despite the improvements achieved.
- Subjects
NORTHERN Italy; GENOA (Italy); COVID-19 pandemic; COVID-19; OLDER people; AGE differences; SARS-CoV-2
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 22, p5239
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10225239