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- Title
Targeting Mitochondria and Metabolism in Acute Kidney Injury.
- Authors
Li, Ying; Hepokoski, Mark; Gu, Wanjun; Simonson, Tatum; Singh, Prabhleen
- Abstract
Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill patients. AKI is also an independent risk factor for the development and progression of chronic kidney disease. Effective therapeutic strategies for AKI are limited, but emerging evidence indicates a prominent role of mitochondrial dysfunction and altered tubular metabolism in the pathogenesis of AKI. Therefore, a comprehensive, mechanistic understanding of mitochondrial function and renal metabolism in AKI may lead to the development of novel therapies in AKI. In this review, we provide an overview of current state of research on the role of mitochondria and tubular metabolism in AKI from both pre-clinical and clinical studies. We also highlight current therapeutic strategies which target mitochondrial function and metabolic pathways for the treatment of AKI.
- Subjects
ACUTE kidney failure; METABOLISM; MITOCHONDRIA; CHRONIC kidney failure; MITOCHONDRIAL pathology; CRITICALLY ill
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 17, p3991
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10173991