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- Title
Association of Stage 1 Hypertension Defined by the ACC/AHA 2017 Guideline With Asymptomatic Coronary Atherosclerosis.
- Authors
Yoon, Yong-Hoon; Park, Gyung-Min; Lee, Jong-Young; Lee, Jae-Hwan; Lee, Hanbyul; Roh, Jae-Hyung; Kim, Ju Hyeon; Lee, Pil Hyung; Choe, Jaewon; Kim, Young-Hak; Lee, Seung-Whan
- Abstract
BACKGROUND This study sought to assess the relationship between stage 1 hypertension and subclinical coronary atherosclerosis. METHODS A total of 4,666 individuals with available coronary computed tomography angiography (CCTA) results from a health checkup were enrolled. The classification of hypertension was adapted from the American College of Cardiology/American Heart Association (ACC/AHA) 2017 guideline. The presence of coronary plaques and its characteristics, and other CCTA findings were assessed. RESULTS There was a linear relationship between blood pressure (BP), both systolic BP (SBP) and diastolic BP (DBP), and the presence of coronary plaque. Patients were classified into 4 groups according to the BP category: normal BP (SBP <120 mm Hg and DBP <80 mm Hg; n = 2,395; 51.3%), elevated BP (SBP 120–129 mm Hg and DBP <80 mm Hg; n = 467; 10.0%), stage 1 hypertension (SBP 130–139 mm Hg or DBP 80–89 mm Hg; n = 1,139; 24.4%), and stage 2 hypertension (SBP ≥140 mm Hg or DBP ≥90 mm Hg; n = 665; 14.2%). Compared with the normal BP group after multivariate adjustment, the stage 1 hypertension group was significantly associated with the presence of atherosclerotic plaque (adjusted odds ratio [95% confidential interval], 1.37 [1.17–1.62]; P < 0.001), especially in noncalcified and mixed plaques. The relationship between stage 1 hypertension and stenosis >50% was not statistically significant. Isolated diastolic and isolated systolic stage 1 hypertensions were significantly related to the presence of coronary plaque. The elevated BP group was not associated with any positive CCTA findings. CONCLUSIONS Stage 1 hypertension was independently associated with subclinical coronary atherosclerosis.
- Subjects
CORONARY artery disease; COMPUTED tomography; HYPERTENSION; BLOOD pressure; ATHEROSCLEROTIC plaque
- Publication
American Journal of Hypertension, 2021, Vol 34, Issue 8, p858
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpab051