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- Title
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy.
- Authors
Ma, Guanqin; Zhang, Deng-Feng; Zou, Qing-Cui; Xie, Xiaochun; Xu, Ling; Feng, Xiao-Li; Li, Xiaohong; Han, Jian-Bao; Yu, Dandan; Deng, Zhong-Hua; Qu, Wang; Long, Junyi; Li, Ming-Hua; Yao, Yong-Gang; Zeng, Jianxiong
- Abstract
To evaluate long-term impact of SARS-CoV-2 infection to the brain, the hACE2 transgenic mice as described previously[7] were intranasally infected with a single low dose (1 × 10 SP 2 sp TCID SB 50 sb ) of prototyped SARS-CoV-2 and maintained for up to 30 days post infection (dpi) (Fig. These authors contributed equally: Guanqin Ma, Deng-Feng Zhang, Qing-Cui Zou, Xiaochun Xie Dear Editor, SARS-CoV-2-induced multi-lineage neural cell dysregulation has been documented[1]. Initially, we conducted co-immunoprecipitation (co-IP) in HEK293T cells and found that SARS-CoV-2 Spike S2 subunit (S-S2), but not S-S1 protein, interacted individually with PEN-2 (Fig. SARS-CoV-2 Spike protein S2 subunit modulates -secretase and enhances amyloid- production in COVID-19 neuropathy.
- Subjects
AMYLOID plaque; AMYLOID beta-protein precursor; SARS-CoV-2; SARS-CoV-2 Omicron variant; COVID-19; PRESENILINS; NEUROPATHY
- Publication
Cell Discovery, 2022, Vol 8, Issue 1, p1
- ISSN
2056-5968
- Publication type
Article
- DOI
10.1038/s41421-022-00458-3