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- Title
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines.
- Authors
Liu, Jiping; Wang, Junbang; Xu, Jinfang; Xia, Han; Wang, Yue; Zhang, Chunxue; Chen, Wei; Zhang, Huina; Liu, Qi; Zhu, Rong; Shi, Yiqi; Shen, Zihao; Xing, Zhonggang; Gao, Wenxia; Zhou, Liqiang; Shao, Jinliang; Shi, Jiayu; Yang, Xuejiao; Deng, Yaxuan; Wu, Li
- Abstract
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
- Subjects
COVID-19 vaccines; MONONUCLEAR leukocytes; COVID-19; TYPE I interferons; COVID-19 pandemic
- Publication
Cell Discovery, 2021, Vol 7, Issue 1, p1
- ISSN
2056-5968
- Publication type
Article
- DOI
10.1038/s41421-021-00329-3