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- Title
Does nickel allergy play a role in the development of in-stent restenosis?
- Authors
El-Mawardy, R.; Fuad, H.; Abdel-Salam, Z.; Ghazy, M.; Nammas, W.
- Abstract
Objectives: It was suggested that coronary in-stent restenosis might be triggered by allergy to nickel and molybdenum ions released from stainless-steel stents. We sought to explore any possible relationship between nickel allergy and in-stent restenosis. Materials and Methods: 50 patients were studied, who underwent elective follow-up coronary angiography for recurrent symptoms after prior coronary stenting, at least 3 months following the index procedure. Consecutively, we enrolled 25 patients with ≥ 50% in-stent restenosis (study group), and 25 others with < 50% restenosis (control group), as revealed by coronary angiography. Evaluation for nickel allergy was performed using 5% nickel sulphate solution in petroleum applied as a patch test to the interscapular region by the Finn chamber method. A positive test was defined as an inflammatory response with erythema, edema, papulovesicles, or infiltration after 48 or 72 hours. Results: The mean age of the whole study cohort was 55.9 ± 13.9 years, 44 (88%) being males. Two patients of the study group (8%) had a history of contact allergy to metals. However, both of them showed a negative patch test result. No patient in the control group had a history of metal allergy (p > 0.05). Only one patient in the study group (4%) had a positive patch test result for nickel contact allergy, whereas all patients in the control group had a negative result (p > 0.05). Conclusions: Based on the available evidence, a cause-effect relationship between nickel allergy and in-stent restenosis cannot be confirmed.
- Subjects
SURGICAL stents; CORONARY restenosis; PHYSIOLOGICAL effects of nickel; NICKEL sulfate
- Publication
European Review for Medical & Pharmacological Sciences, 2011, Vol 15, Issue 11, p1235
- ISSN
1128-3602
- Publication type
Article