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- Title
Neisseria meningitidisC:2b:P1.2,5 with decreased susceptibility to penicillin isolated from a patient with meningitis and purpura fulminans.
- Authors
Fangio, P.; Desbouchages, L.; Lachérade, J.; Jonghe, B.; Terville, J.; Leneveu, M.; Outin, H.
- Abstract
This report describes the case of an 18-year-old woman with meningococcal meningitis and purpura fulminans. Cerebrospinal fluid culture revealedNeisseria meningitidisserogroup-serotype-serosubtype C:2b:P1.2,5 as the pathogenic organism. Following treatment with cefotaxime and management of multiple organ failure, the patient survived without sequelae. To the best of our knowledge this report represents the first case of a meningococcal strain with a minimum inhibitory concentration of 1.5 µg/ml for penicillin, without ß-lactamase production, to be documented in France. The prevalence of meningococci with reduced susceptibility to penicillin is increasing. The emergence of such strains might represent a serious problem affecting the empirical antibiotic treatment of meningococcal disease.
- Subjects
NEISSERIA meningitidis; PENICILLIN; MENINGITIS; CEREBROSPINAL fluid; CEFOTAXIME; ANTIBIOTICS
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2005, Vol 24, Issue 2, p140
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-005-1283-0