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- Title
The Role of Non-Ionic Surfactants in Solubilization and Delivery of Sparingly Soluble Drug Naproxen Sodium (NS): A Case Study.
- Authors
Khattak, Noor Saeed; Shah, Luqman Ali; Sohail, Muhammad; Ahmad, Safeer; Farooq, Muhammad; Ara, Latafat; Kader, Safaa I.
- Abstract
Nonsteroidal anti-inflammatory hydrophobic drugs (NSAIDs) are amongst the most commonly given categories of drugs worldwide in the treatment of pain, irritation and some of them even fever in many conditions. Critical micelle concentration of NSAIDs with Naproxen sodium (NS) and its mixture with non-ionic surfactants i.e. Tween 20, Tween 40 and Tween 60 was investigated at 293 K, 303 K, 313 K and 323 K at different concentrations using surface tension and dynamic laser light scattering (DLS) techniques. Due to amphiphilic behaviour in aqueous solution NS form aggregates at sufficiently high concentration. Thermodynamic/adsorption properties like free energy of micellization (ΔGmic), enthalpy of micellization (ΔHmic), entropy of micellization (ΔSmic), Gmic and area per molecule (A2) ofNS in the presence of surfactantswere also measured at different temperatures. The results showed that the presence of surfactants favoured the ΔGmic and become more enhanced with increase in temperature. Further the solubility of drug is more favourable with increase in polyethylene chain in basic surfactant molecules i.e. 20-60, which indicates that Tween-60 enhanced the solubility of NS more comparatively to Tween-40 and Tween-20 and may be applied as best additive for solubilisation of NS.
- Subjects
NONIONIC surfactants; CRITICAL micelle concentration; SOLUBILIZATION; DRUG solubility; SURFACE tension; NAPROXEN
- Publication
Zeitschrift für Physikalische Chemie, 2019, Vol 233, Issue 7, p933
- ISSN
0942-9352
- Publication type
Article
- DOI
10.1515/zpch-2018-1241