We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cancer Cachexia: Underlying Mechanisms and Potential Therapeutic Interventions.
- Authors
Directo, Dean; Lee, Sang-Rok
- Abstract
Cancer cachexia, a multifactorial metabolic syndrome developed during malignant tumor growth, is characterized by an accelerated loss of body weight accompanied by the depletion of skeletal muscle mass. This debilitating condition is associated with muscle degradation, impaired immune function, reduced functional capacity, compromised quality of life, and diminished survival in cancer patients. Despite the lack of the known capability of fully reversing or ameliorating this condition, ongoing research is shedding light on promising preclinical approaches that target the disrupted mechanisms in the pathophysiology of cancer cachexia. This comprehensive review delves into critical aspects of cancer cachexia, including its underlying pathophysiological mechanisms, preclinical models for studying the progression of cancer cachexia, methods for clinical assessment, relevant biomarkers, and potential therapeutic strategies. These discussions collectively aim to contribute to the evolving foundation for effective, multifaceted counteractive strategies against this challenging condition.
- Subjects
CACHEXIA; WEIGHT loss; MUSCLE mass; BODY weight; SKELETAL muscle
- Publication
Metabolites (2218-1989), 2023, Vol 13, Issue 9, p1024
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo13091024