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- Title
Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients.
- Authors
Malý, Martin; Hajšl, Martin; Bechyňská, Kamila; Kučerka, Ondřej; Šrámek, Martin; Suttnar, Jiří; Hlaváčková, Alžběta; Hajšlová, Jana; Kosek, Vít
- Abstract
Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment.
- Subjects
ACUTE coronary syndrome; ISCHEMIC stroke; STROKE patients; HIGH performance liquid chromatography; LOW density lipoproteins; OXIDATIVE stress; LIPID metabolism
- Publication
Metabolites (2218-1989), 2021, Vol 11, Issue 7, p412
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo11070412