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- Title
Abnormal expression of the co‐stimulatory molecule B7‐H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.
- Authors
Feng, X.; Yang, M.; Yang, Z.; Qian, Q.; Burns, E. M.; Min, W.
- Abstract
Summary: Background: The co‐stimulatory molecule B7‐H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC). Aim: To investigate if abnormal expression of the co‐stimulatory molecule B7‐H3 in LSC is associated with Langerhans cell (LC) expansion. Methods: We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7‐H3 and interleukin (IL)‐6 was significantly different. Results: Our results indicated that B7‐H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL‐6 might modulate B7‐H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells. Conclusions: Our study indicates the potential value of immunotherapy as a treatment for LSC.
- Subjects
LANGERHANS cells; MEMBRANE glycoproteins; MOLECULES; T cells; SKIN diseases
- Publication
Clinical & Experimental Dermatology, 2020, Vol 45, Issue 1, p30
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.14001