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- Title
A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma.
- Authors
Dongying Gu; Mingliang He; Lee, Nikki P.; Zhi Xu; Jinfei Chen
- Abstract
The Hippo pathway plays an important role in the development of hepatocellular carcinoma (HCC). The present study aimed at exploring the genetic variants of Hippo pathway-related genes and their association with HCC prognosis. A total of 331 HCC patients who tested positive for hepatitis B surface antigen were recruited in this study. None of the patients had prior surgical treatment. Twelve potentially functional single-nucleotide polymorphisms (rs7317471 andrs9509492inLATS2;rs4810446,rs2267853,rs8000,andrs6073627inMST1;rs10955176 in MST2; andrs16861979, rs2043550, rs16861985, rs1055153, andrs7630434 in TAZ) in the Hippo pathway were genotyped from patients' peripheral leukocytes using the Sequenom MassARRAY iPLEX platform. Cox proportional hazard models and log-rank test were used for the survival analyses. LATS2 rs7317471 OT polymorphism was significantly associated with decreased risk of death in HCC using the dominant model (adjusted hazard ratio [HR] =0.63, 95% confidence interval [CI] =0.46-0.87, P=0.004). Furthermore, using stratified analysis, LATS2 rs7317471 CT/TT genotypes were found to be significantly associated with decreased risk of death in patients who were below 53 years of age (adjusted HR =0.50), females (adjusted HR =0.60), smokers (adjusted HR =0.56), drinkers (adjusted HR =0.58), have Barcelona clinic liver cancer stage B (adjusted HR =0.62), and received no prior chemotherapy or transcatheter hepatic arterial chemoembolization (adjusted HR =0.48). Our results suggested that LATS2 rs7317471 could be used as a potential biomarker for the prediction of HCC prognosis.
- Subjects
CANCER prognosis; HEPATITIS B; SINGLE nucleotide polymorphisms; LEUCOCYTES; HIPPO signaling pathway; HEPATOCELLULAR carcinoma
- Publication
OncoTargets & Therapy, 2016, Vol 9, p1945
- ISSN
1178-6930
- Publication type
Article