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- Title
Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus-related hepatocellular carcinoma.
- Authors
Kubo, Shoji; Nishiguchi, Shuhei; Hirohashi, Kazuhiro; Tanaka, Hiromu; Tsukamoto, Tadashi; Hamba, Hiroyuki; Shuto, Taichi; Yamamoto, Takatsugu; Ikebe, Takashi; Kinoshita, Hiroaki; Kubo, S; Nishiguchi, S; Hirohashi, K; Tanaka, H; Tsukamoto, T; Hamba, H; Shuto, T; Yamamoto, T; Ikebe, T; Kinoshita, H
- Abstract
<bold>Background: </bold>The effect of prior hepatitis B virus (HBV) infection on the clinicopathologic findings for patients with hepatitis C virus (HCV) RNA and hepatocellular carcinoma (HCC) is still unclear.<bold>Methods: </bold>Of 59 patients who underwent liver resection for HCV-related HCC (</=2.0 cm in greatest dimension) without metastases between 1990 and 1997, 38 patients had anti-HB core antibody (anti-HBc) and did not have HB surface antigen in their sera (Group 1). Their clinicopathologic findings and outcomes after surgery were compared with those of the remaining 22 patients without anti-HBc (Group 2).<bold>Results: </bold>The proportion of well-differentiated HCC was significantly lower in Group 1 than in Group 2 (P = 0.0214). The percentage of patients with cirrhosis was significantly lower in Group 1 than in Group 2 (P = 0.0228). The cumulative survival rate was significantly lower in Group 1 than in Group 2 (P = 0.0224). The risk ratio of anti-HBc for shorter survival time was 3.817.<bold>Conclusions: </bold>HCC more often developed before cirrhosis in patients with HCV RNA and anti-HBc than in patients positive for HCV RNA alone. Prior HBV infection was a risk factor for poor outcome after liver resection for patients infected with HCV.
- Publication
Cancer (0008543X), 1999, Vol 86, Issue 5, p793
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-0142(19990901)86:5<793::AID-CNCR14>3.0.CO;2-K