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- Title
Minocycline HC1 Microspheres Reduce Red-Complex Bacteria in Periodontal Disease Therapy.
- Authors
Goodson, J. Max; Gunsolley, John C.; Grossi, Sara G.; Bland, Paul S.; Otomo-Corgel, Joan; Doherty, Frances; Comiskey, Judy
- Abstract
Background: The objective of this trial was to measure the antimicrobial effects of a minocycline HCI microsphere (MM) local drug-delivery system when used as an adjunct to scaling and root planing (SRP). DNA probe analysis for 40 bacteria was used to evaluate the oral bacteria of 127 subjects with moderate to advanced chronic periodontitis. Methods: Subjects were randomly assigned to either SRP alone (N = 65) or MM + SRP (N = 62). The primary endpoints of this study were changes in numbers and proportions of the red complex bacteria (RCB) and the sum of Porphyromonas gingivalis, Tannerella forsythia (formally T. forsythensis), and Treponema denticola relative to 40 oral bacteria at each test site from baseline to day 30. Numbers of RCB from the five test sites were averaged to provide a value for each subject. Results: MM + SRP reduced the proportion of RCB by 6.49% and the numbers by 9.4 x 105. The reduction in RCB proportions and numbers by SRP alone (5.03 % and 5.1 x 105, respectively) was significantly less. In addition, MM + SRP reduced probing depth by 1.38 mm (compared to 1.01 mm by SRP alone), bleeding on probing was reduced by 25.2% (compared to 13.8% by SRP alone), and a clinical attachment level gain of 1.16 mm (compared to 0.80 mm by SRP alone) was achieved. Conclusion: These observations support the hypothesis that RCBs are responsible for periodontal disease and that local antimicrobial therapy using MM + SRP effectively reduces numbers of RCBs and their proportions to a greater extent than SRP alone.
- Subjects
UNITED States; MICROSPHERES; HYDROGEN chloride; DRUG delivery systems; DENTAL scaling; PATHOGENIC bacteria; PERIODONTAL disease treatment; CLINICAL trials
- Publication
Journal of Periodontology, 2007, Vol 78, Issue 8, p1568
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2007.060488