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- Title
Schistosomiasis Japonica During Pregnancy Is Associated With Elevated Endotoxin Levels in Maternal and Placental Compartments.
- Authors
McDonald, Emily A.; Pond-Tor, Sunthorn; Jarilla, Blanca; Sagliba, Marianne J.; Gonzal, Annaliza; Amoylen, Amabelle J.; Olveda, Remigio; Acosta, Luz; Gundogan, Fusun; Ganley-Leal, Lisa M.; Kurtis, Jonathan D.; Friedman, Jennifer F.
- Abstract
Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.
- Subjects
SCHISTOSOMA japonicum; ENDOTOXINS; PLACENTA; CELL compartmentation; SCHISTOSOMIASIS; PREGNANCY complications
- Publication
Journal of Infectious Diseases, 2014, Vol 209, Issue 3, p468
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jit446