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- Title
The impact of regimented aminophylline use on extracardiac radioisotope activity in patients undergoing regadenoson stress SPECT myocardial perfusion imaging: A substudy of the ASSUAGE trial.
- Authors
Ballany, Wassim; Mansour, Khaled; Morales Demori, Raysa; Al-Amoodi, Mohammed; Doukky, Rami
- Abstract
Background: In patients undergoing regadenoson stress SPECT myocardial perfusion imaging (MPI), the impact of the regimented administration of aminophylline on the cardiac-to-extracardiac photon activity ratio is unknown. Methods: This is a substudy of the ASSUAGE trial (NCT01250496); a double-blinded, randomized, placebo-controlled clinical trial which investigated the attenuation of regadenoson-related adverse effects using 75 mg of intravenous aminophylline vs placebo, administered 90 seconds following Tc-tetrofosmin injection in patients undergoing regadenoson stress SPECT-MPI. In subjects with normal MPI enrolled in the trial, we sampled from the antero-posterior planar projection of the post-stress scintigraphic data the mean photon activity in the myocardium, liver, bowel, and lungs. The mean cardiac-to-extracardiac activity ratios were compared between patients randomized to aminophylline vs placebo. Results: We studied 158 eligible subjects, randomized to receive aminophylline (n = 86) or placebo (n = 72). The means of photon activity ratios of the heart-to-liver, heart-to-bowel, heart-to-lungs, inferior wall of the heart-to-liver, and inferior wall of the heart-to-bowel were not statistically different between those who received aminophylline vs placebo ( P values > .30). Only the time lapse between stress Tc-tetrofosmin injection and stress SPECT acquisition independently correlated with higher heart-to-liver and heart-to-bowel activity ratios ( P values ≤ .01). Patients' body mass index independently correlated with lower heart-to-lung ratio ( P = .009). Conclusion: The regimented intravenous aminophylline use following regadenoson stress does not significantly improve the cardiac-to-extracardiac photon activity ratio in patients undergoing regadenoson stress Tc-tetrofosmin SPECT-MPI.
- Subjects
AMINOPHYLLINE (Drug); RADIOISOTOPES; PURINES; MYOCARDIAL perfusion imaging; MYOCARDIUM; BODY mass index; IMAGE quality analysis
- Publication
Journal of Nuclear Cardiology, 2014, Vol 21, Issue 3, p496
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-014-9864-x