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- Title
Criteria for evaluation of disease extent by (123)I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force.
- Authors
Matthay, K. K.; Shulkin, B; Ladenstein, R; Michon, J.; Giammarile, F.; Lewington, V.; Pearson, A. DJ; Cohn, S. L.; Pearson, A D J
- Abstract
<bold>Background: </bold>Neuroblastoma is an embryonic tumour of the sympathetic nervous system, metastatic in half of the patients at diagnosis, with a high preponderance of osteomedullary disease, making accurate evaluation of metastatic sites and response to therapy challenging. Metaiodobenzylguanidine (mIBG), taken into cells via the norepinephrine transporter, provides a sensitive and specific method of assessing tumour in both soft tissue and bone sites. The goal of this report was to develop consensus guidelines for the use of mIBG scans in staging, response assessment and surveillance in neuroblastoma.<bold>Methods: </bold>The International Neuroblastoma Risk Group (INRG) Task Force, including a multidisciplinary group in paediatric oncology of North and South America, Europe, Oceania and Asia, formed a subcommittee on metastatic disease evaluation, including expert nuclear medicine physicians and oncologists, who developed these guidelines based on their experience and the medical literature, with approval by the larger INRG Task Force.<bold>Results: </bold>Guidelines for patient preparation, radiotracer administration, techniques of scanning including timing, energy, specific views, and use of single photon emission computed tomography are included. Optimal timing of scans in relation to therapy and for surveillance is reviewed. Validated semi-quantitative scoring methods in current use are reviewed, with recommendations for use in prognosis and response evaluation.<bold>Conclusions: </bold>Metaiodobenzylguanidine scans are the most sensitive and specific method of staging and response evaluation in neuroblastoma, particularly when used with a semi-quantitative scoring method. Use of the optimal techniques for mIBG in staging and response, including a semi-quantitative score, is essential for evaluation of the efficacy of new therapy.
- Subjects
NEUROBLASTOMA; CANCER patients; GUANETHIDINE derivatives; NORADRENALINE; TOMOGRAPHY; HEALTH risk assessment; DIAGNOSIS; BONE tumors; COMPARATIVE studies; DIAGNOSTIC imaging; RESEARCH methodology; MEDICAL cooperation; MEDICAL protocols; METASTASIS; POLICY sciences; RADIATION injuries; RADIOPHARMACEUTICALS; RESEARCH; SOFT tissue tumors; TUMOR classification; EVALUATION research; SINGLE-photon emission computed tomography; BENZENE derivatives; IODINE radioisotopes; PREVENTION
- Publication
British Journal of Cancer, 2010, Vol 102, Issue 9, p1319
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605621