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- Title
Pattern of cancer risk in persons with AIDS in Italy in the HAART era.
- Authors
Dal Maso, L.; Polesel, J.; Serraino, D.; Lise, M.; Piselli, P.; Falcini, F.; Russo, A.; Intrieri, T.; Vercelli, M.; Zambon, P.; Tagliabue, G.; Zanetti, R.; Federico, M.; Limina, R. M.; Mangone, L.; De Lisi, V.; Stracci, F.; Ferretti, S.; Piffer, S.; Budroni, M.
- Abstract
A record-linkage study was carried out between the Italian AIDS Registry and 24 Italian cancer registries to compare cancer excess among persons with HIV/AIDS (PWHA) before and after the introduction of highly active antiretroviral therapy (HAART) in 1996. Standardised incidence ratios (SIR) were computed in 21951 AIDS cases aged 16-69 years reported between 1986 and 2005. Of 101 669 person-years available, 45 026 were after 1996. SIR for Kaposi sarcoma (KS) and non-Hodgkin lymphoma greatly decreased in 1997-2004 compared with 1986-1996, but high SIRs for KS persisted in the increasingly large fraction of PWHA who had an interval of <1 year between first HIV-positive test and AIDS diagnosis. A significant excess of liver cancer (SIR=6.4) emerged in 1997-2004, whereas the SIRs for cancer of the cervix (41.5), anus (44.0), lung (4.1), brain (3.2), skin (non-melanoma, 1.8), Hodgkin lymphoma (20.7), myeloma (3.9), and non-AIDS-defining cancers (2.2) were similarly elevated in the two periods. The excess of some potentially preventable cancers in PWHA suggests that HAART use must be accompanied by cancer-prevention strategies, notably antismoking and cervical cancer screening programmes. Improvements in the timely identification of HIV-positive individuals are also a priority in Italy to avoid the adverse consequences of delayed HAART use.
- Subjects
ITALY; HIGHLY active antiretroviral therapy; HEPATITIS viruses; PAPILLOMAVIRUS diseases; AIDS; EPIDEMIOLOGY; RISK assessment; CANCER patients
- Publication
British Journal of Cancer, 2009, Vol 100, Issue 5, p840
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6604923