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- Title
Delta-9-Tetrahydrocannabinol, the Major Psychoactive Component in Marijuana, Inhibits Macrophage Chemotaxis to Acanthamoeba.
- Authors
MARCIANO-CABRAL, FRANCINE; RABORN, ERINN S.; MARTIN, BILLY R.; CABRAL, GUY A.
- Abstract
The article examines the migratory responsiveness of macrophages to Acanthamoeba to obtain insight into processes that are operative within the host that are affected by delta- 9-tetrahydrocannabinol (THC) and that account for increased mortality. THC has been reported to inhibit macrophage functions including migration, nitric oxide production, lysis of bacteria, and tumor cells. The results indicate that THC inhibits the macrophage chemotactic response to Acanthamoeba.
- Subjects
ACANTHAMOEBA; ACANTHAMOEBIDAE; TETRAHYDROCANNABINOL; CANNABINOIDS; PATHOGENIC microorganisms; MACROPHAGES; ANTIGEN presenting cells
- Publication
Journal of Eukaryotic Microbiology, 2006, Vol 53, pS15
- ISSN
1066-5234
- Publication type
Article
- DOI
10.1111/j.1550-7408.2006.00158.x