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- Title
Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index.
- Authors
Murphy EL; Fang J; Tu Y; Cable R; Hillyer CD; Sacher R; Triulzi D; Gottschall JL; Busch MP; Murphy, Edward L; Fang, Junyong; Tu, Yongling; Cable, Ritchard; Hillyer, Christopher D; Sacher, Ronald; Triulzi, Darrell; Gottschall, Jerome L; Busch, Michael P; Retrovirus Epidemiology Donor Study
- Abstract
<bold>Background: </bold>During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking.<bold>Methods: </bold>We performed a large, cross-sectional study of blood donors at 6 US blood centers during 2006-2007. Anti-HCV was measured with enzyme-linked immunosorbent assay followed by immunoblot, and HCV RNA was measured with nucleic acid testing. Adjusted odds ratios (aORs) were derived using multivariable logistic regression.<bold>Results: </bold>Of 959,281 donors, 695 had anti-HCV detected (prevalence, 0.072%). Of those with anti-HCV, 516 (74%) had test results positive for HCV RNA, and 179 (26%) had test results that were negative for HCV RNA. Compared with the prevalence during the period 1992-1993, prevalence during 2006-2007 was lower and peaked in older age groups. Anti-HCV was associated with a body mass index (BMI) >30 (aOR, 0.6; 95% confidence interval [CI], 0.5-0.8), and among women, it was associated with higher gravidity (aOR for 5 vs 0 pregnancies, 3.2; 95% CI, 1.9-5.4). HCV RNA negative status was associated with black race (aOR, 0.4; 95% CI, 0.2-0.7), having more than a high school education (aOR, 1.6; 95% CI, 1.1-2.4), and BMI >30 (aOR, 2.4; 95% CI, 1.4-3.9).<bold>Conclusions: </bold>Decreasing HCV prevalence is most likely attributable to culling of seropositive donors and a birth cohort effect. We found new associations between anti-HCV prevalence and gravidity and obesity. Recently discovered genetic factors may underlie differences in HCV RNA clearance in black donors.
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 4, p576
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/654882