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- Title
14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients.
- Authors
Brandel, Jean-Philippe; Peoc'h, Katell; Beaudry, Patrice; Welaratne, Arlette; Bottos, Corinne; Agid, Yves; Laplanche, Jean-Louis; Brandel, J P; Peoc'h, K; Beaudry, P; Welaratne, A; Bottos, C; Agid, Y; Laplanche, J L
- Abstract
The usefulness of the detection of 14-3-3 protein in the cerebrospinal fluid (CSF) in the diagnosis of Creutzfeldt-Jakob disease transmitted from human growth hormone was evaluated in 20 French patients. The 14-3-3 protein was rarely detectable within the first 3 months of the disease but always positive after 7 months associated with the aggravation of the disease and the occurrence of dementia. 14-3-3 detection was not predictive of the survival time of the patients. The genotype at PRNP codon 129 could influence the timing of appearance of the 14-3-3 protein in the CSF.
- Publication
Annals of Neurology, 2001, Vol 49, Issue 2, p257
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/1531-8249(20010201)49:2<257::AID-ANA48>3.0.CO;2-X