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- Title
Immunotherapy: Current Status and Future Perspectives.
- Authors
Floudas, Charalampos S.; Brar, Gagandeep; Greten, Tim F.
- Abstract
Hepatocellular carcinoma (HCC) has an increasing incidence and dismal prognosis, with few systemic treatments approved, including several small molecule tyrosine kinase inhibitors. The application of immune checkpoint inhibitors (ICIs) to HCC has resulted in durable activity, and further evaluation is ongoing. In this review, we discuss the immunologic principles and the mechanism of action of the ICIs and present the relevant clinical data. Furthermore, we provide an overview of the current and emerging immunotherapeutic approaches for HCC, such as combination treatments, vaccines, and cellular therapies.
- Subjects
IMMUNOTHERAPY; SMALL molecules; PROTEIN-tyrosine kinases; HEPATOCELLULAR carcinoma; CELLULAR therapy
- Publication
Digestive Diseases & Sciences, 2019, Vol 64, Issue 4, p1030
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-019-05516-7