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- Title
Preliminary Neurocognitive Results Post Hypoglossal Nerve Stimulation in Patients With Down Syndrome.
- Authors
Grieco, Julie A.; Hartnick, Christopher J.; Skotko, Brian G.; Yu, Phoebe K.; Pulsifer, Margaret B.
- Abstract
Hypoglossal nerve stimulation (HGS) is a safe and effective intervention to treat obstructive sleep apnea (OSA) among typically developing individuals.1,2 Effective management of OSA has demonstrated improvements in neurocognitive and behavioral functioning in neurotypical children.3-6 Children with Down syndrome (DS) have a high incidence of OSA, with approximately 80% diagnosed compared to <5% in the general pediatric population.7 Residual OSA after adenotonsillectomy is common and minimally invasive therapy (continuous positive airway pressure [cPAP]) can have limited effectiveness in this population due to reduced tolerability.8 When untreated, residual OSA in children with DS can affect their neurocognitive abilities, with one study documenting a lower verbal IQ by approximately nine points.9 HGS is currently being investigated at Massachusetts Eye and Ear Infirmary (NCT0234418) to assess safety, OSA severity reduction, and sleep quality among children and adolescents with DS. DISCUSSION This pilot study examined neurocognitive and behavioral outcomes in a small cohort of pediatric patients with DS and severe OSA following HGS. CONCLUSION Treatment of severe OSA using HGS in nine pediatric patients with DS resulted in clinically meaningful improvements in neurocognitive and behavioral functioning.
- Subjects
PEOPLE with Down syndrome; HYPOGLOSSAL nerve; NEURAL stimulation; WECHSLER Intelligence Scale for Children; WECHSLER Adult Intelligence Scale; VERBAL behavior
- Publication
Laryngoscope, 2021, Vol 131, Issue 12, p2830
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.29808