We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The aetiologies of central nervous system infections in hospitalised Cambodian children.
- Authors
Paul Turner; Kuong Suy; Le Van Tan; Pora Sar; Thyl Miliya; Nguyen Thi Thu Hong; Vu Thi Ty Hang; Nguyen Thi Han Ny; Sona Soeng; Day, Nicholas P. J.; van Doorn, H. Rogier; Turner, Claudia; Turner, Paul; Suy, Kuong; Tan, Le Van; Sar, Pora; Miliya, Thyl; Hong, Nguyen Thi Thu; Hang, Vu Thi Ty; Ny, Nguyen Thi Han
- Abstract
<bold>Background: </bold>Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia.<bold>Methods: </bold>We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens. Viral metagenomics was performed on a subset of pathogen negative specimens.<bold>Results: </bold>Between 1st October 2014 and 30th September 2015, 284 analysable patients were enrolled. The median patient age was 2.6 years; 62.0% were aged <5 years. CSF white blood cell count was ≥10 cells/μL in 116/272 (42.6%) cases. CNS infection was microbiologically confirmed in 55 children (19.3%). Enteroviruses (21/55), Japanese encephalitis virus (17/55), and Streptococcus pneumoniae (7/55) accounted for 45 (81.8%) of all pathogens identified. Of the pathogens detected, 74.5% (41/55) were viruses and 23.6% (13/55) were bacteria. The majority of patients were treated with ceftriaxone empirically. The case fatality rate was 2.5%.<bold>Conclusions: </bold>Enteroviruses, JEV and S. pneumoniae are the most frequently detected causes of CNS infection in hospitalised Cambodian children.
- Subjects
CAMBODIA; CENTRAL nervous system diseases; CHILD mortality; CEREBROSPINAL fluid; POLYMERASE chain reaction; SEROLOGY; ENTEROVIRUSES; STREPTOCOCCUS pneumoniae; ANTIBIOTICS; HOSPITAL care of children; COMPARATIVE studies; ENTEROVIRUS diseases; FLAVIVIRUSES; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STREPTOCOCCUS; CENTRAL nervous system infections; EVALUATION research; THERAPEUTICS
- Publication
BMC Infectious Diseases, 2017, Vol 17, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-017-2915-6