We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Key to Increase Immunogenicity of Next‐Generation COVID‐19 Vaccines Lies in the Inclusion of the SARS‐CoV‐2 Nucleocapsid Protein.
- Authors
Mendoza-Ramírez, Noe Juvenal; García-Cordero, Julio; Shrivastava, Gaurav; Cedillo-Barrón, Leticia; Amdare, Nitin
- Abstract
Vaccination is one of the most effective prophylactic public health interventions for the prevention of infectious diseases such as coronavirus disease (COVID‐19). Considering the ongoing need for new COVID‐19 vaccines, it is crucial to modify our approach and incorporate more conserved regions of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) to effectively address emerging viral variants. The nucleocapsid protein is a structural protein of SARS‐CoV‐2 that is involved in replication and immune responses. Furthermore, this protein offers significant advantages owing to the minimal accumulation of mutations over time and the inclusion of key T‐cell epitopes critical for SARS‐CoV‐2 immunity. A novel strategy that may be suitable for the new generation of vaccines against COVID‐19 is to use a combination of antigens, including the spike and nucleocapsid proteins, to elicit robust humoral and potent cellular immune responses, along with long‐lasting immunity. The strategic use of multiple antigens aims to enhance vaccine efficacy and broaden protection against viruses, including their variants. The immune response against the nucleocapsid protein from other coronavirus is long‐lasting, and it can persist up to 11 years post‐infection. Thus, the incorporation of nucleocapsids (N) into vaccine design adds an important dimension to vaccination efforts and holds promise for bolstering the ability to combat COVID‐19 effectively. In this review, we summarize the preclinical studies that evaluated the use of the nucleocapsid protein as antigen. This study discusses the use of nucleocapsid alone and its combination with spike protein or other proteins of SARS‐CoV‐2.
- Publication
Journal of Immunology Research, 2024, Vol 2024, p1
- ISSN
2314-8861
- Publication type
Article
- DOI
10.1155/2024/9313267