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- Title
The relationship between Geriatric Nutritional Risk Index (GNRI) and in-hospital mortality in critically ill patients with Acute Kidney Injury (AKI).
- Authors
Zhao, Dong; Zhou, Dawei; Li, Tong; Wang, Chao; Fei, Shuyang
- Abstract
Background: The role of the geriatric nutritional risk index (GNRI) as a prognostic factor in intensive care unit (ICU) patients with acute kidney injury (AKI) remains uncertain. Objectives: The aim of this study was to investigate the impact of the GNRI on mortality outcomes in critically ill patients with AKI. Methods: For this retrospective study, we included 12,058 patients who were diagnosed with AKI based on ICD-9 codes from the eICU Collaborative Research Database. Based on the values of GNRI, nutrition-related risks were categorized into four groups: major risk (GNRI < 82), moderate risk (82 ≤ GNRI < 92), low risk (92 ≤ GNRI < 98), and no risk (GNRI ≥ 98). Multivariate analysis was used to evaluate the relationship between GNRI and outcomes. Results: Patients with higher nutrition-related risk tended to be older, female, had lower blood pressure, lower body mass index, and more comorbidities. Multivariate analysis showed GNRI scores were associated with in-hospital mortality. (Major risk vs. No risk: OR, 95% CI: 1.90, 1.54–2.33, P < 0.001, P for trend < 0.001). Moreover, increased nutrition-related risk was negatively associated with the length of hospital stay (Coefficient: -0.033; P < 0.001) and the length of ICU stay (Coefficient: -0.108; P < 0.001). The association between GNRI scores and the risks of in-hospital mortality was consistent in all subgroups. Conclusions: GNRI serves as a significant nutrition assessment tool that is pivotal to predicting the prognosis of critically ill patients with AKI.
- Subjects
RISK assessment; CRITICALLY ill; PATIENTS; NUTRITIONAL assessment; QUESTIONNAIRES; SEX distribution; ACUTE kidney failure; CATASTROPHIC illness; RETROSPECTIVE studies; MULTIVARIATE analysis; AGE distribution; HOSPITAL mortality; DESCRIPTIVE statistics; ODDS ratio; INTENSIVE care units; GERIATRIC nutrition; CONFIDENCE intervals; LENGTH of stay in hospitals
- Publication
BMC Anesthesiology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-024-02689-1