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- Title
Penetration of isavuconazole into the epithelial lining fluid of patients with pulmonary fungal infections. Comment on: 'Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions'.
- Authors
Maillard, Alexis; Bournaud, Léo Froelicher; Pastre, Jean; Planquette, Benjamin; Parize, Perrine; Lanternier, Fanny; Rasmussen, Camille; Chenevier-Gobeaux, Camille; Cheurfa, Cherifa; Benaboud, Sihem; Charlier, Caroline; Canouï, Etienne
- Abstract
This article examines the penetration of isavuconazole, a drug used to treat pulmonary fungal infections, into the epithelial lining fluid (ELF) of patients. The authors emphasize the importance of understanding how the drug diffuses into the lungs for effective treatment. They discuss the results of previous studies on healthy volunteers and lung transplant recipients, which showed varying concentrations of the drug in the ELF. However, there is a lack of data on non-lung transplanted patients with fungal infections. The authors conducted a case series with three patients and found moderate and variable penetration of isavuconazole into the ELF. Further research is needed to confirm these findings. Another article in the same document focuses on the impact of the COVID-19 pandemic on mental health. The authors discuss the psychological effects of the pandemic, including increased anxiety, depression, and stress. They stress the importance of addressing mental health issues during this time and provide recommendations for individuals and healthcare professionals. The article emphasizes the need for more research and support to mitigate the long-term consequences of the pandemic on mental well-being.
- Subjects
INFORMED consent (Medical law); LIQUID chromatography-mass spectrometry; PULMONARY aspergillosis; DRUG monitoring; DRUG dosage; RITUXIMAB
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2024, Vol 79, Issue 9, p2403
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkae258