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- Title
Mechanism of Mitochondrial Homeostasis Controlling Ovarian Physiology.
- Authors
Tian, Yuan; Liu, Xinrui; Pei, Xiuying; Gao, Hui; Pan, Pengge; Yang, Yanzhou
- Abstract
Ovarian cells, including oocytes, granulosa/cumulus cells, theca cells, and stromal cells, contain abundant mitochondria, which play indispensable roles in the processes of ovarian follicle development. Ovarian function is closely controlled by mitochondrial proteostasis and mitostasis. While mitochondrial proteostasis and mitostasis are disturbed by several factors, leading to dysfunction of ovarian function and initiating the mitochondrial unfolded protein response (UPRmt) and mitophagy to maintain or recover ovarian function and mitochondrial function, clear interactions between the 2 pathways in the ovary have not been fully elucidated. Here, we comprehensively summarize the molecular networks or regulatory mechanisms behind further mitochondrial research in the ovary. This review provides novel insights into the interactions between the UPRmt and mitophagy in ovarian functions.
- Subjects
UNFOLDED protein response; OVARIAN follicle; REACTIVE oxygen species; MITOCHONDRIAL proteins; STROMAL cells
- Publication
Endocrinology, 2024, Vol 165, Issue 9, p1
- ISSN
0013-7227
- Publication type
Article
- DOI
10.1210/endocr/bqac189