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- Title
Impact of Baseline Anti-ABO Antibody Titer on Biliary Complications in ABO-Incompatible Living-Donor Liver Transplantation.
- Authors
Yu, Se-Hyeon; Jo, Hye-Sung; Yu, Young-Dong; Park, Pyoung-Jae; Han, Hyung-Joon; Kim, Sang-Jin; Kamarulzaman, Syahrul Hadi; Kim, Dong-Sik
- Abstract
Background: Although advancements in desensitization protocols have led to increased ABO-incompatible (ABOi) living-donor liver transplantation (LDLT), a higher biliary complication rate remains a problem. This study evaluated the effect of baseline anti-ABO antibody titers before desensitization on biliary complications after ABOi LDLT. Methods: The study cohort comprised 116 patients in the ABO-compatible group (ABOc), 29 in the ABOi with the low titer (<1:128) group (ABOi-L), and 14 in the high titer (≥1:128) group (ABOi-H). Results: Biliary complications occurred more frequently in the ABOi-H group than in the ABOi-L and ABOc groups (7 [50.0%] vs. 8 [27.6%] and 24 [20.7%], respectively, p = 0.041). Biliary complication-free survival was significantly worse in the ABOi-H group than in the other groups (p = 0.043). Diffuse intrahepatic biliary strictures occurred more frequently in the ABOi-H group than in the other groups (p = 0.005). Multivariable analysis revealed that the high anti-ABO antibody titer (≥1:128) is an independent risk factor for biliary complications (hazard ratio 3.943 [1.635–9.506]; p = 0.002). Conclusions: A high baseline anti-ABO antibody titer (≥1:128), female sex, and hepatic artery complications are significant risk factors for biliary complications.
- Subjects
ANTIBODY titer; HEPATIC artery; MEDICAL protocols; LIVER transplantation; BLOOD group incompatibility
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 16, p4789
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13164789