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- Title
Clinical Features and Vaccination Effects among Children with Post-Acute Sequelae of COVID-19 in Taiwan.
- Authors
Hsu, Yu-Lung; Chen, Pei-Chi; Tsai, Yi-Fen; Wei, Chi-Hung; Wu, Lawrence Shi-Hsin; Hsieh, Kai-Sheng; Hsieh, Miao-Hsi; Lai, Huan-Cheng; Lin, Chien-Heng; Lin, Hsiao-Chuan; Chen, Chieh-Ho; Chen, An-Chyi; Lin, Hung-Chih; Chou, I-Ching; Soong, Wen-Jue; Hwang, Kao-Pin; Lu, Henry Horng-Shing; Pawankar, Ruby; Tsai, Hui-Ju; Wang, Jiu-Yao
- Abstract
Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) affects patients after recovering from acute coronavirus disease 2019 (COVID-19). This study investigates the impact of SARS-CoV-2 vaccination on PASC symptoms in children in Taiwan during the Omicron pandemic. Methods: We enrolled children under 18 years with PASC symptoms persisting for more than 4 weeks. Data collected included demographics, clinical information, vaccination status, and symptom persistence. We used logistic regression models to compare symptoms in the acute and post-COVID-19 phases and to assess the association between vaccination and these symptoms. Results: Among 500 PASC children, 292 (58.4%) were vaccinated, 282 (52.8%) were male, and the mean (SD) age was 7.6 (4.6) years. Vaccinated individuals exhibited higher odds of experiencing symptoms in the previous acute phase, such as cough (adjusted odds ratio [AOR] = 1.57; 95% confidence interval [CI]: 1.02–2.42), rhinorrhea/nasal congestion (AOR = 1.74; 95% CI: 1.13–2.67), sneezing (AOR = 1.68; 95% CI: 1.02–2.76), sputum production (AOR = 1.91; 95% CI: 1.15–3.19), headache/dizziness (AOR = 1.73; 95% CI: 1.04–2.87), and muscle soreness (AOR = 2.33; 95% CI: 1.13–4.80). In contrast, there were lower odds of experiencing abdominal pain (AOR = 0.49; 95% CI: 0.25–0.94) and diarrhea (AOR = 0.37; 95% CI: 0.17–0.78) in children who had received vaccination during the post-COVID-19 phase. Conclusions: This study revealed clinical features and vaccination effects in PASC children in Taiwan. Vaccination may reduce some gastrointestinal symptoms in the post-COVID-19 phase.
- Subjects
POST-acute COVID-19 syndrome; COVID-19; VACCINATION status; MYALGIA; SARS-CoV-2 Omicron variant; COUGH
- Publication
Vaccines, 2024, Vol 12, Issue 8, p910
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines12080910