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- Title
Structural vaccinology starts to deliver.
- Authors
Dormitzer, Philip R.; Grandi, Guido; Rappuoli, Rino
- Abstract
Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens.
- Subjects
GENOMICS; ANTIGENS; PATHOGENIC microorganisms; VACCINE research; EPITOPES
- Publication
Nature Reviews Microbiology, 2012, Vol 10, Issue 12, p807
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2893