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- Title
Circulating Obestatin Levels Correlate with Fasting Insulin and HOMA-IR but Not with Hypertension in Elderly Men.
- Authors
Shao, Li; Zhao, Yin-tao; Teng, Li-li; Li, Ming-zhu; Jiang, Hua
- Abstract
Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. The association between circulating obestatin levels and blood pressure remains unclear. Furthermore, adequate information is non-existent regarding the older male population with hypertension. For this purpose, we enrolled 185 unrelated hypertensive male patients aged ≥80 years (range 80-102 years). One hundred seventy nine age-matched healthy subjects served as controls. Plasma levels of obestatin and insulin were measured using commercial ELISA and RIA. HOMA-IR was calculated using standard method. We found that plasma obestatin levels correlated significantly with insulin levels ( P = 0.034) and homeostasis model assessment index for insulin resistance (HOMA-IR: P = 0.028). However, plasma obestatin differed non-significantly between hypertensive (5.06 ± 0.68 ng/mL) and non-hypertensive (4.72 ± 0.82 ng/mL) individuals. Plasma obestatin levels were not associated with systolic ( P = 0.818) or diastolic ( P = 0.564) blood pressure, waist-to-hip ratio (WHR: P = 0.725), uric acid ( P = 0.603), total cholesterol (TC: P = 0.589), low-density lipoprotein cholesterol (LDL-C: P = 0.057); high-density lipoprotein cholesterol (HDL-C: P = 0.432), triglyceride (TG: P = 0.418), and fasting blood glucose (FBG: P = 0.101). We, therefore, concluded that fasting circulating obestatin levels did not directly correlate with blood pressure in men aged ≥80 years.
- Subjects
HYPERTENSION in old age; DISEASES in older people; BLOOD pressure; FASTING; INSULIN; MEDICINE information services
- Publication
Cell Biochemistry & Biophysics, 2014, Vol 69, Issue 1, p89
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-013-9772-8