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- Title
The Impact of Magnesium on Isometric Twitch Parameters and Resting Membrane Potential of the Skeletal Muscle in Diabetic Rats.
- Authors
Pelit, Aykut; Emre, Mustafa; Dağli, Kenan; Tuli, Abdullah
- Abstract
To present the relationship between oral magnesium supplementation, blood glucose, and changes in isometric twitch parameters, resting membrane potential (RMP), in the gastrocnemius muscle in diabetic rats. Sixty rats were used in this study. The rats were divided into four groups: control (drinking tap water, Group I, n = 15), control with treated with magnesium sulfate (10 g/L) (Group II, n = 15), diabetic (Group III, n = 15), and diabetic with treated with magnesium sulfate (10 g/L) (Group IV, n = 15). In Group II and IV, the level of plasma magnesium was increased comparing to those of the control group ( p < 0.05). Isometric twitch tensions were decreased significantly in the Group III, but Group IV isometric twitch tensions were increased significantly. Group IV RMP values were close to the Group I. Hyperglycemia decreases gastrocnemius muscle isometric twitch tension and increases RMP in diabetic rats. Magnesium treatment can prevent these diabetic complications.
- Subjects
THERAPEUTIC use of magnesium; MEMBRANE potential; SKELETAL muscle; HYPERGLYCEMIA; ISOMETRIC exercise
- Publication
Cell Biochemistry & Biophysics, 2013, Vol 65, Issue 3, p315
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-012-9434-2